DISSOLUTION RATE ENHANCEMENT AND PHYSICOCHEMICAL CHARACTERIZATION OF RIVAROXABAN SOLID DISPERSIONS WITH POLOXAMER 188
نویسندگان
چکیده
The aim of the work was to enhance dissolution rate rivaroxaban by preparing its solid dispersions (SDs) using hydrophilic carrier poloxamer 188. prepared were characterized Fourier-transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC). Both solubility drug in these formulations increased. SDs with 188 at 1:1, 1:2 1:3 w/w ratios physical mixing, melting solvent evaporation techniques. used showed more than two fold increase their or FTIR spectroscopic DCS thermal studies compatibility absence well-defined polymer interactions, though shift peaks observed due formation new bonds.
منابع مشابه
Preparation and characterization of celecoxib solid dispersions; comparison of poloxamer-188 and PVP-K30 as carriers
Objective(s):Solid dispersion formulation is the most promising strategy to improve oral bioavailability of poorly water soluble drugs. The aim of this study was to compare the effect of polyvinylpyrrolidone K30 (PVP) and poloxamer-188 (PLX) as carrier in solid dispersion formulations of celecoxib (CLX). Materials and Methods: Solid dispersions of CLX:PVP or CLX:PLX were prepared at different r...
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preparation and characterization of celecoxib solid dispersions; comparison of poloxamer-188 and pvp-k30 as carriers
objective(s):solid dispersion formulation is the most promising strategy to improve oral bioavailability of poorly water soluble drugs. the aim of this study was to compare the effect of polyvinylpyrrolidone k30 (pvp) and poloxamer-188 (plx) as carrier in solid dispersion formulations of celecoxib (clx). materials and methods: solid dispersions of clx:pvp or clx:plx were prepared at different r...
متن کاملPreparation and characterization of celecoxib solid dispersions; comparison of poloxamer-188 and PVP-K30 as carriers
OBJECTIVES Solid dispersion formulation is the most promising strategy to improve oral bioavailability of poorly water soluble drugs. The aim of this study was to compare the effect of polyvinylpyrrolidone K30 (PVP) and poloxamer-188 (PLX) as carrier in solid dispersion formulations of celecoxib (CLX). MATERIALS AND METHODS Solid dispersions of CLX:PVP or CLX:PLX were prepared at different ra...
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ژورنال
عنوان ژورنال: Journal of Pharmaceutical Negative Results
سال: 2022
ISSN: ['0976-9234', '2229-7723']
DOI: https://doi.org/10.47750/pnr.2022.13.s08.238